BMT

What is Sickle Cell Anemia?

Sickle Cell Anemia

A genetic blood disorder that tends to pass along from one generation to the next is known as Sickle Cell Anemia. Usually, RBCs have a disc-like shape which gives them the flexibility to travel through even the smallest blood vessels in the body. But in sickle cell disease, the RBCs have an abnormal shape resembling a crescent moon or a sickle and they become rigid and sticky as well. As a result, they get trapped in the small vessels and cause severe damage and pain in the body.

Types

  • Hemoglobin SS disease (HbSS) – when a person inherits the hemoglobin S gene from each of the parents.
  • Hemoglobin SC disease (HbSC) – when a person inherits the Hb C gene from one of the parents and the Hb S from the other one.
  • Hemoglobin SB+ (beta) thalassemia – when a person inherits the sickle cell gene from one of the parents and the beta-thalassemia gene from the other parents.
  • Hemoglobin SD, SE, and SO – rarest form
  • Sickle Cell Trait – when a person inherits one sickle cell gene and will not have sickle cell disease but can pass the gene to their children.

Treatment

Bone marrow transplant or Stem cell transplant is the only known cure for sickle cell anemia. In this procedure, damaged cells are replaced with new cells with the help of IV infusion.

Procedure for Bone Marrow Transplant

The treatment usually begins with chemotherapy to create space for healthy cells. After that, healthy stem cells are infused through an IV, as done in blood transfusion. There is not any surgical procedure involved in this process.

Risks factors

  • Infections
  • Bleeding
  • Transplant failure

Prevention

PGD IVF: There is a procedure to avoid passing the genes of sickle cell to the baby, known as a preimplantation genetic diagnosis. It is performed during in vitro fertilization (IVF) to thoroughly examine embryos to select sickle-free embryos for transfer or implantation.

PRENATAL TESTS: It is a test that is done to check whether the baby has or has not inherited genes from the parents before giving birth.

There are two types of tests:

  1. Chorionic Villus sampling (CVS)
  2. Amniocentesis

Some Facts About half match & full match BMT in Sickle Cell Anemia

Number of days taken for initial investigations 10
Number of days in Hepa filter room 25-30
Number of days in Room 0
Follow up days 75
Total days required to stay overseas for treatment 115

Role of Parishay Healthcare in Planning Treatment for Sickle Cell Anemia!

After you contact us, a relationship manager is allocated to you who arranges a teleconsultation with an excellent healthcare provider according to your need. After your consent, we move forward with your untroubled travel arrangements, treatment plan, and follow-up care.

For more information visit our website www.parishayafrica.com

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